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In bone and joint infections, 150 mg kg day not to exceed the maximum adult dosage is recommended in equally divided doses every hours. Invert the bottle and vigorously rock the bottle from side to side so that water rises through the powder. DRUG INTERACTIONS In common with other antibiotics, cefuroxime may affect the gut flora, leading to lower estrogen reabsorption and reduced efficacy of cefuroxime prescription combined estrogen progesterone oral contraceptives. Talk to your doctor before using this form of cefuroxime if you have phenylketonuria PKU. Cefuroxime can make birth control pills less effective, which may result in pregnancy. Therefore, elderly people may be at greater risk for side effects while using this drug. Prescribed For: Cefuroxime is effective against susceptible bacterias causing infections of the middle ear, tonsillitis, throat infections, laryngitis, bronchitis, and pneumonia.